"Estamos indo para a casa do meu irmão."

Translation: We are going to my brother's house.

[nicoruizm]

Home and house are sinonims. Both can be correct

[JoanaNahor]

Yes, but.... Home is like "lar" in portuguese, and we don't speak this way. House is use more often for translate only "casa".
You are correct, both mean the "same".