"This medicine will make you feel better."
Translation:Este remédio fará com que você se sinta melhor.
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Both "fará que" and "fará com que" can be used here, but the second one just sounds better and you'll hear most native speakers talking like that. It's a weird exception to the rule that a verb that needs a direct object can't have a preposition. I don't know why it happens, but when "fazer" has the meaning of to cause/to induce, that's how people say it.