Not when they are qualifying a noun, like in this sentence. Think of nagy épületeket as one grammatical unit, which only needs to take the accusative (and the plural) suffix once - on the noun at the end.
If the adjective is standing alone, behaving as a noun itself rather than modifying some other noun, then it will take any endings that a noun would take in the same place.
Hol látsz sárga búszokat? - Where do you see yellow buses?
Hol látsz sárgákat? - Where do you see yellow ones / yellow things?