People may find it a bit unusual if you say "meduka" because people are a bit used to hear the common mistake "meduke". But it's not so very bad, and importantly, it is not related to gender. Nobody says "meduka" about a female, not even in error, everybody uses "meduket", which is correct.
(As a side note, some people argue that "meduket" is incorrect and you should say "meduka'a" מדוכאה. I agree with jg9000 that they are both correct).