Yes. It means "how is everything (family, etc) at home"

Si. significa ; come vanno le cose a casa? tutto bene?

If you've been living away from home, you might say this near the start of a phone call

Also, if you have not seen a person for a while you would ask about all the family, and this is not uncommon (to start the conversation). It is part of the normal, polite greetings.