"What is the orientation of your house?"
Translation:Quelle est l'orientation de ta maison ?
"quel" implies a choice: "quelle est l'orientation...?" (could be west, north...), i.e. it means "which"
it is an adjective, so it has to agree in gender and number with its noun: quelle orientation, quel chapeau, quels amis, quelles fraises...
"que" is a pronoun, ie it works like a noun and can be an object: que voulez-vous ?