No, you have to repeat the subject in the form of a pronoun or use "est-ce que":

• est-ce que les animaux sont espagnols ?

or, rare: sont-ce des animaux espagnols ?

Because it's false. You can't translate word by word, unfortunately...

You missed the verb.

What you propose back translates to "is it that animals from Spain?"

In addition, you should translate an adjective to an adjective: espagnols = Spanish (not 'from Spain').

And unfortunately "they are from Spain" does not translate word to word: "ils sont originaires d'Espagne".

"elles" would refer to a feminine noun, whereas "un animal / des animaux" is a masculine noun.

in addition, the feminine of "espagnols" is "espagnoles "

The animals can come from Spain and not be Spanish; or can be Spanish and not travelling.