Translation:Where is the house?
Note that there is a は after いえ. This makes it much more probable that the sentence is about a house.
If it is a sentence with いいえ the next word is often not a particle:
No, I don't eat. いいえ、たべません。
No, it's a room. いいえ、へやです。
But something like this should be possible:
A "No" is difficult. 「いいえ」はむずかしい。
Also, いいえ sounds longer than いえ. ;)