Translation:With great power come great responsibilities.
You are correct jolynnedougherty. "With great power COMES great responsibility" or "With great powers COME great responsibilites". It's one or the other to be grammatically correct. Not "With great power come great responsibilites." Come has to agree with power. Power COMES, not power come.
I tripped there, as well. It's the lingering question with Duo about whether we have to translate the given phrase word-for-word, or translate the meaning of the phrase. I agree that grammatically the verb should be plural, but the gist, at least as Uncle Ben phrased it, is that responsibility is singular and all-encompassing.
And yes, I've already put more thought into this that I should. :->