"What does he mean?"
Translation:Was meint er?
Yeah, depends on the pronoun - http://www.verbix.com/webverbix/German/meinen.html
The verb meinen (to mean) is used here. This is different than meinen (mine).
Meint er es. -He means it. Meint is the conjugated form for he/she/it
Putting that into question form: Was meint er? Literal: What means he? Grammatically correct: What does he mean?
German has some words already built into the verbs, so 'does' isn't needed.
I'm not a native speaker, but that's how I understand it.
Hope this helps.