"Máte na rukou jeho krev!"

Translation: You have his blood on your hands!

[JohnBraga1]

Surely "you have his blood on your hand" is also correct? The given answer (hands plural) presumably is figurative.

[tragram]

But the Czech sentences also uses the plural (well, technically dual but let's not get into that :D)!

[DOette]

Why wasn't hand in the locative case?

[endless_sleeper]

It is. You need the peculiar dual endings for body parts here. Check the tips and notes.

[Stephen900455]

Is the Czech sentence literal or figurative?

[VladaFu]

Could be either in either language.