When speaking in Mandarin, I believe that they would use 块/毛/分. However, when speaking in the local dialect/language (Cantonese) they would definitely not (they would instead use 蚊/毫/仙). But again, 块/毛/分 really shouldn't be restricted to any currency. Sinophones outside of China will use 块/毛/分 for the local currency.
The second character 块 seems to indirectly indicate that the currency is yuan.