"What should I do?"
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Why are we saying 怎么 here and not 什么?
If we are asking the question in the sense of 'what should I do (e.g., to resolve a problem)', then I understand 怎么 - we are essentially asking how to accomplish some goal.
But if we are asking 'what should I do (e.g., with the rest of my life)', then its really a question of What, not How... so 什么?