"¿Sabe usted dónde está la universidad?"
Translation:Do you know where the university is?
The word is "about," not "bout." "Bout" is a word that means "fight," as in professional boxing.
The interrogative adverbs used in questions are why, where, how, & when. These adverbs are placed at the question's beginning. Interrogative sentences are typically marked by inversion of the subject and predicate; that is, the first verb in a verb phrase–also known as the helping verb–appears before the subject, as in "Do you know where the university is?"
It could be "sabes." If duo gives you the English to translate, "sabes" should be accepted as well as "sabe usted." There is nothing in the English to tell you which to use. In fact, "saben ustedes" should also be correct here.