"¿Cuándo salieron ustedes de casa?"
Translation:When did you all leave home?
It's hard to say that sentence without sounding like you are slurring your words. That's how it sounded the first time anyway. She must have stolen the bottle of wine from the fishes.
Also correct should be "when did you leave from home."
In English, there can be a slight difference between "leave home' and "leave from home."
"Leave home" can refer to "leaving home for good" as in "moving out." "Leave from home" can imply a temporary departure "leave home to go to school".