I think this could be a sentence that pops up when you (and your companion) (it's in plural form) realize that you're locked and trapped in the lion cage in the zoo while it's about time to feed the animals.
Smelling fresh flesh, the lions wake up, stretch their bodies, yawn, look in your direction, and start to move.....
I think that would be an appropriate time to use this sentence.
It's also useful for other occasions as well of course, this was just the first thing that came to my mind.
Dear Jo, yes you are more than 100% right, "end of relationship", also possible, actually a fact of life.
I'm not proud of it, but I have to admit that I've heard this sentence a couple of times in my life already, and it was never in a cage in the zoo.
Anyway, let's try to end on a slightly more positive note, there is another situation when you can use this, ...in a computer game...you and your clan are surrounded, outnumbered and outgunned, and it's almost game over..... eehhhmmm...not really positive...but it's less traumatic and you can restart the game.
Ini adalah akhir dari kita…..It's a dramatic sentence isn't it !?
Could be the title of a story or a book.