Translation:The boy and the girl are children.
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In French, it is always necessary to put an article before nouns.
In this case, you need to put the indefinite plural article "des".
The 3rd person plural of verb "être" is "sont" ("sommes" is the 1st person plural of this verb "être").
There is no phonetic difference between "son" (possessive adjective) and "sont" (3rd person plural of verb "être").
Because "les" is a definite article. Here you need an indefinite article meaning that that they are "children" in general, not "the children" (in particular).
To use "les", you would need more information after "children", for example:
- "Le garçon et la fille sont les enfants de mes voisins." means "The boy and the girl are the children of my neighbors."