no. Isso, isto and aquilo are always neutral, that is, have no gender or number.
Ok, I didn't put Issa, but for some reason I always want to tack an 'a' for feminine words.
The tips for the demonstrative lesson advises to avoid using isto/isso/aquilo for people and animals because it treats them like objects.
What makes "isso" the right choice instead of "esse?" Would "esse" be wrong in this context?