"Was ist mit meiner Untersuchung?"

[Sk8rMom]

I was tempted to write "What is with my check-up?" but did not want to risk a heart. "Check-up" should work, too, right?

[marziotta]

I would translate as "What's wrong about my examination?"
"Was ist mit" is often used with a negative nuance, as far as I understood.

[cayvie]

at least in American English, "what is with" carries a similar negative connotation

[vitoreiji]

Does "what is it with" mean the same thing?

[cephalium]

I had the same response! The translation was not checked by a native English spaeker

[Glutexo]

You are right!

[heshmati]

Could "What is wrong with my analysis" be also right?

[Glutexo]

Yes.

[jaye16]

Although I keep writing "What is with...." to keep my hearts I still feel it is regional Am. english and shouldn't be here.